Preparation and Characterization of Ibrutinib Phytosome First with Egg Phosphatidylglycerol
Ibrutinib(IBR) is a potent, covalent inhibitor of Brutons tyrosine kinase(BTK), a kinase downstream of the B-cell receptor that is critical for B-cell survival and proliferation.As a new antitumor drug, ibrutinib is rapidly absorbed and eliminated after oral administration resulting on its low bioavailability.This study was aimed to develop ibrutinib-loaded phytosomes to improve ibrutinib bioavailability with sufficient safety and stability.This system consists of ibrutinib and egg phosphatidylgycerol prepared by solvent evaporation method.The result demonstrated that molar ratio of 1:1 showed satisfying properties with mean vesicle diameter of (32.0 ± 1.82) nm and Zeta potential of(8.01 ± 0.15) mV.It showed good stability after freeze thaw stability test.Analysis of FTIR spectroscopy and DSC was confirmed the presence of physical and chemical interactions between ibrutinib and phospholipid complex.Well formed and discrete vesicles of phytosome were revealed by Transmission Electron Microscopy.
Mei Lu Xiang Luo Cunyang Wang Jing Sun Yang Liu Xiangyun Lin Yihui Deng
College of Pharmacy, Shenyang Pharmaceutical University,Shenyang 110016, P.R.China
国际会议
沈阳
英文
344-346
2016-04-28（万方平台首次上网日期，不代表论文的发表时间）