The reversal MDR effect study of cholesterol-coupled TPGS loaded DTX Micelles

摘要：

　　In this study, a kind of novel TPGS derivative,cholesterol-coupled TPGS (TPGS-CHMC), was used to prepare micelles with Docetaxel (DTX) by a self-assembly method.A2780/r cells were used to evaluate the reversal MDR effect of the micelles.As a result, blank TPGS-CHMC micelles showed antitumor effect which was significantly stronger than Tween 80/DTX solution (P < 0.01) and the TPGS-CHMC/DTX micelles exhibited the highest inhibition rate for 72.32%.From the point of weight change, the blank TPGS-CHMC micelles were similar with normal saline, the weight rising slowly.However, the weight decreased slightly in the TPGS-CHMC/DTX micelles.

作者: Yiwen Cui Lei Shang Tang Li Jia Shi Le Kang Yihui Deng Yanzhi Song

作者单位: College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, P.R.China China Medical University, Shenyang, 110001, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 347-348

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）