The antioxidants selection of VK2 oral submicron emulsion by classical isothermal kinetic method

摘要：

　　Through preliminary experiments, we found the results of using a single antioxidant that vitamin K2 oral submicro emulsion extending shelf life is not satisfactory.Therefore, we will use antioxidant and chelating agent in combination in order to obtain a longer validity period of preparation.We prepared four kinds of vitamin K2 formulations and their shelf life was predicted to choose the proper antioxidants and chelating agent.Arrhenius equation was used to predict the shelf life of each formulation.Results show that shelf life of formulation without antioxidant and metal ion chelating agent are only 36 days while calcium disodium edetate respectively with vitamin E and ascorbyl palmitate can prolong the shelf life to 2.13 and 2.36 years.

作者: Jia Shi Yanzhi Song Rui Feng Lili Duan Jiepeng Chen Xuan Li Yihui Deng

作者单位: College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110016, China Sungen Biotech Co., Ltd., Shantou, Guangdong, 515000, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 349-351

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）