A cyclic hexapeptide conjugated nanoparticles enhances curcumin delivery to the tumor vasculature and tumor cells

摘要：

　　Herein we report the preparation and in-vitro evaluation of curcumin nanoparticles (CUR-NPs).To direct the curcumin nanoparticles to tumor, we applied a cyclic hexapeptide c (RGDf(N-me)VK)-C as the target ligand.The results showed the targeted CUR-NPs (c (RGDf(N-me)VK)-C modified) had a better binding and uptake ability than the targeted NPs (c (RGDf(N-me)V modified)and non-targeted NPs.

作者: Xuemei Zhang Xuejuan Li Jingjing Li Aiping Wang Kaoxiang Sun Wanhui Liu Youxin Li

作者单位: School of Pharmacy, Yantai University, Yantai, Shandong, 264005, China;State Key Laboratory of Long- School of Pharmacy, Yantai University, Yantai, Shandong, 264005, China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 362-363

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）