Preparation and characterization of anti-EphA10 decorated pH-sensitive siRNA-liposomes complexes

摘要：

　　Therapeutic delivery of small interfering RNA remains a major challenge that limits its potent clinical application.In this study, a pH sensitive PEG-schiff base-cholesterol (Chol-SIB-PEG) vas modified on cationic liposomes (PSL).To enhance targeting ability, anti-EphA 10 monoclonal antibody (Eph) was conjugated to the liposomes (EPSL).The MDR1-siRNA was incorporated into liposomes to siRNA-liposomes complexes (EPSLR) through electric interactions.The electrophoresis results showed that siRNA-liposomes complexes could bind tightly and restrain heparin displacement.EPSLR was also characterized with encapsulation efficiency.

作者: Xinlong Zang Xiaowei Li Zhouqi Du Haiyang Hu Mingxi Qiao Dawei Chen Xiuli Zhao

作者单位: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaonig, 110016,PR China

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 371-373

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）