In vitro study of magnetically and pH responsive dendrosomes for tumor-targeted hybrid drug delivery

摘要：

　　Magnetically and pH dual responsive dendrosomes were prepared by encapsulating magnetic nanoparticles and dendrimers in pH sensitive liposomes.In vitro release results showed the pH sensitivity of Mag-pH-DS.The hybrid vectors showed superior cellular uptake in slightly acid environments compared with in pH7.4 environments due to rapid release.In multicellular tumor spheroids tests (MCTSs), a slightly acidic environment and the application of magnet both promoted the permeation efficiency of the hybrid vectors.The multifunctional dendrosomes were demonstrated to have great potential as a promising anticancer drug delivery platform.

作者: Meng Wang Hongjie Mu Xumei Zhang Kaoxiang Sun

作者单位: School of Pharmacy, Yantai University, Yantai, Shandong province, 264005, P.R.China School of Pharmacy, Yantai University, Yantai, Shandong province, 264005, P.R.China;State Key Labora

会议类型: 国际会议

会议名称: The 4th Asian Symposium on Pharmaceutical Science and Technology & Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences (第四届亚洲药剂学论坛暨亚洲药物制剂科学杂志编委会扩大会议)

会议地点: 沈阳

会议语种:英文

页码: 391-392

在线出版日期: 2016-04-28（万方平台首次上网日期，不代表论文的发表时间）