Predictive accuracy of Sepsis-3 definitions for mortality among adult critically ill patients with suspected infection
Background: Sepsis-3 definitions have been published recently;however, their diagnostic value remains controversial.This study was to assess the accuracy of Sepsis-3 definitions compared to Sepsis-1 definitions by stratifying mortality among adult critically ill patients with suspected infection.Methods: A multicenter, prospective cohort study was conducted from November 10, 2017 to October 10, 2018, in five Intensive Care Units (ICUs) at four teaching hospitals.Thirty-day mortality was compared across categories for both Sepsis-3 definitions and Sepsis-1 definitions, which were evaluated by logistic regression analysis followed by measurement of the area under the receiver operating characteristic curve (AUROC) for predicting 30-day mortality rates.Results: Of the 749 enrolled patients, 644 (85.9%) were diagnosed with sepsis according to the Sepsis-1 definitions.Among those patients, 362 were diagnosed with septic shock (362/749, 48.3%).However, according to the Sepsis-3 definitions, there were 483 patients with a diagnosis of sepsis (483/749, 64.5%), among whom 299 patients were diagnosed with septic shock (299/749,39.9%).According to the Sepsis-3 definitions, sepsis (sepsis and septic shock) patients had higher 30-day mortality (41.8%) than sepsis patients according to the Sepsis-1 definitions (31.8%, x2=5.552, P =0.020).The AUROC of systemic inflammatory response syndrome (SIRS) and quick sequential organ failure assessment (qSOFA) scores with regard to 30-day mortality rates were 0.609 (0.566-0.652) and 0.694 (0.654-0.733), respectively.However, the AUROC of SOFA scores (0.828 0.795-0.862) were significantly higher than that of SIRS or qSOFA scores (P < 0.001).Conclusion: In adult critically ill patients with suspected infection, the Sepsis-3 definitions were relatively accurate in stratifying mortality and were superior to the Sepsis-1 definitions.
Infection Critically ill patients Sepsis-3 Septic shock Mortality
Qi-Hong Chen Jun Shao Wei-Li Liu Hua-Ling Wang Lei Liu Xiao-Hua Gu Rui-Qiang Zheng
Department of Critical Care Medicine, Jiangdu Peoples Hospital of Yangzhou, Jiangdu Peoples Hospit Department of Critical Care Medicine, Northern Jiangsu Peoples Hospital, Clinical Medical College, Department of Intensive Care Unit, Affiliated Hospital of Yangzhou University, Yangzhou University, Department of Cardiology, Northern Jiangsu Peoples Hospital, Clinical Medical College of Yangzhou U
国际会议
珠海
英文
1147-1153
2019-05-23（万方平台首次上网日期，不代表论文的发表时间）