会议专题

Roles of short-chain fatty acids in kidney diseases

  Objective: In kidney diseases, uncontrolled blood pressure, inflammation, oxidative stress, imbalanced immunity response, and metabolic dysfunction were associated with the progressive deterioration of renal function.Short-chain fatty acids (SCFAs), as a group of metabolites fermented by gut microbiota exerted regulatory effects on kidney diseases through their activation of transmembrane G protein-coupled receptors and their inhibition of histone acetylation.In this review article, we updated recent research advances that provided an opportunity to explore our understanding in physiology and function of SCFAs in kidney disease.Data sources: We performed a comprehensive search in both PubMed and Embase using short-chain fatty acids and kidney with no restrictions on publication date.Study selection: After reading through the title and abstract for early screening, the full text of relevant studies was identified and reviewed to summarize the roles of SCFAs in kidney diseases.Results: Though controversial, growing evidence suggested SCFAs appeared to have a complex but yet poorly understood communications with cellular and molecular processes that affected kidney function and responses to injury.From recent studies,SCFAs influenced multiple aspects of renal physiology including inflammation and immunity, fibrosis, blood pressure, and energy metabolism.Conclusions: The roles of intestinal SCFAs in kidney diseases were exciting regions in recent years;however, clinical trials and animal experiments in kidney diseases were still lacked.Thus, more research would be needed to obtain better understanding of SCFAs potential effects in kidney diseases.

Gut microbiome Short-chain fatty acid Kidney disease Gut-kidney axis

Ling-Zhi Li Si-Bei Tao Liang Ma Ping Fu

Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China;D

国际会议

中华医学会第13次全国重症医学大会

珠海

英文

1228-1232

2019-05-23(万方平台首次上网日期,不代表论文的发表时间)