Injectable hydrogel for central nervous system tissue repair

摘要：

　　Development of cystic cavities following traumatic spinal cord injury is a major hurdle for regenerative approaches to improve functional recovery.Axonal regeneration from severed host neurons would not occur in the cystic spaces without the presence of proteinaceous extracellular matrix (ECM).Infiltration of endogenous or grafted stem or progenitor cells would be greatly diminished in the fluid-filled cysts.Implantation of scaffolding biomaterials has been regarded as a promising approach to overcome this problem (Tsintou et al., 2015).Indeed, successful obliteration of experimental spinal cord lesions was reported using predesigned solid type of scaffolds (Teng et al., 2002;Hwang et al., 2011).Considering irregular and unpredictable geometry of human spinal cord lesions, however, clinically useful materials should be injectable to accommodate highly variable nature of traumatic lesions.Here, we discuss advantages and disadvantages in employing injectable hydrogel scaffolds to bridge cystic cavities following spinal cord trauma.In addition, we present our recent study where injectable hydrogel successfully prevented cavity formation by promoting extracellular matrix remodeling (Hong et al., 2017).

作者: Hee Hwan Park Dong Hoon Hwang Byung Gon Kim

作者单位: Department of Brain Science, Ajou University School of Medicine, Suwon, Republic of Korea;Neuroscien Department of Brain Science, Ajou University School of Medicine, Suwon, Republic of Korea;Department

会议类型: 国际会议

会议名称: Joint symposium of 2018 International Neural Regeneration Symposium、11th Asia Pacific Symposium on Neural Regeneration 、 2018 International Spinal Cord Injury Treatments and Trials Symposium 、2nd Annual Meeting of Neural Regeneration and Repair Committee(

会议地点: 广州

会议语种:英文

页码: 21-23

在线出版日期: 2018-07-26（万方平台首次上网日期，不代表论文的发表时间）