Stem cells for spinal cord injuries bearing translational potential
Spinal cord injury (SCI) is a highly debilitating neurological disease, which still lacks effective treatment strategies, causing significant financial burden and distress to the affected families.Nevertheless, nanotechnology and regenerative medicine strategies holding promise for the development of novel therapies that would reach from bench to bedside to serve the SCI patients.There has already been significant progress in the field of cell-based therapies, with the clinical application for SCI, currently in phase Ⅱ of the clinical trial.Stem cells (e.g., induced pluripotent stem cells, fetal stem cells, human embryonic stem cells, and olfactory ensheathing cells) are certainly not to be considered the panacea for neural repair but, especially when combined with rehabilitation or other combinatorial approaches using the help of nanotechnology,they seem to be the source of some of the most promising and clinical translatable cell-based therapies that could help solving impactful problems on neural repair.
spinal cord injury stem cells neuroregeneration plasticity repair
Kyriakos Dalamagkas Magdalini Tsintou Alexander M.Seifalian
Department of Tissue Engineering, Harvard Medical School, Boston, MA, USA;Nanotechnology & Regenerat Nanotechnology & Regenerative Medicine Commercialisation Centre (Ltd.), The London BioScience Innova
国际会议
广州
英文
108-115
2018-07-26（万方平台首次上网日期，不代表论文的发表时间）