Schwann cell development, maturation and regeneration: a focus on classic and emerging intracellular signaling pathways
The development, maturation and regeneration of Schwann cells (SCs), the main glial cells of the peripheral nervous system, require the coordinate and complementary interaction among several factors, signals and intracellular pathways.These regulatory molecules consist of integrins, neuregulins, growth factors,hormones, neurotransmitters, as well as entire intracellular pathways including protein-kinase A, C, Akt,Erk/MAPK, Hippo, mTOR, etc.For instance, Hippo pathway is overall involved in proliferation, apoptosis,regeneration and organ size control, being crucial in cancer proliferation process.In SCs, Hippo is linked to merlin and YAP/TAZ signaling and it seems to respond to mechanic/physical challenges.Recently, among factors regulating SCs, also the signaling intermediates Src tyrosine kinase and focal adhesion kinase (FAK) proved relevant for SC fate, participating in the regulation of adhesion, motility, migration and in vitro myelination.In SCs, the factors Src and FAK are regulated by the neuroactive steroid allopregnanolone, thus corroborating the importance of this steroid in the control of SC maturation.In this review, we illustrate some old and novel signaling pathways modulating SC biology and functions during the different developmental, mature and regenerative states.
myelin neuroactive steroids electromagneticfield peripheral nervous system
Luca Franco Castelnovo Veronica Bonalume Simona Melfi Marinella Ballabio Deborah Colleoni Valerio Magnaghi
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy
国际会议
广州
英文
172-182
2018-07-26（万方平台首次上网日期，不代表论文的发表时间）