Regulation of neuronal survival by DNA methyltransferases
The limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, age-associated diseases as well as during the development of the nervous system.Subordinate to genetic networks epigenetic mechanisms like DNA methylation and histone modifications are involved in the regulation of neuronal development, function and aging.DNA methylation by DNA methyltransferases (DNMTs), mostly correlated with gene silencing, is a dynamic and reversible process.In addition to their canonical actions performing cytosine methylation, DNMTs influence gene expression by interactions with histone modifying enzymes or complexes increasing the complexity of epigenetic transcriptional networks.DNMTs are expressed in neuronal progenitors, post-mitotic as well as adult neurons.In this review, we discuss the role and mode of actions of DNMTs including downstream networks in the regulation of neuronal survival in the developing and aging nervous system and its relevance for associated disorders.
DNA methyltransferase 1 cortical interneurons PAK6 neuronal aging neuropsychiatric diseases neurodevelopment neuronal death
Judit Symmank Geraldine Zimmer
Institute of Human Genetics, University Hospital Jena, Jena, Germany
国际会议
广州
英文
193-200
2018-07-26（万方平台首次上网日期，不代表论文的发表时间）