Automated and Robust Geographic Atrophy Segmentation for Time Series SD-OCT Images
Geographic atrophy(GA),mainly characterized by atrophy of the retinal pigment epithelium(RPE),is an advanced form of age-related macular degeneration(AMD)which will lead to vision loss.Automated and robust GA segmentation in three-dimensional(3D)spectral-domain optical coherence tomography(SD-OCT)images is still an enormous challenge.This paper presents an automated and robust GA segmentation method based on object tracking strategy for time series SD-OCT volumetric images.Considering the sheer volume of data,it is unrealistic for experts to segment GA lesion region manually.However,in our proposed scenario,experts only need to manually calibrate GA lesion area for the first moment of each patient,and then the GA of the following moments will be automatically detected.In order to fully embody the outstanding features of GA,a new sample construction method is proposed for more effectively extracting histogram of oriented gradient(HOG)features to generate random forest models.The experiments on SD-OCT cubes from 10 eyes in 7 patients with GA demonstrate that our results have a high correlation with the manual segmentations.The average of correlation coefficients and overlap ratio for GA projection area are 0.9881 and 82.62%,respectively.
Geographic atrophy HOG features Image segmentation Spectral-domain optical coherence tomography
Yuchun Li Sijie Niu Zexuan Ji Qiang Chen
School of Computer Science and Engineering,Nanjing University of Science and Technology,Nanjing,Chin School of Information Science and Engineering,University of Jinan,Jinan,China School of Computer Science and Engineering,Nanjing University of Science and Technology,Nanjing,Chin
国际会议
广州
英文
249-261
2018-11-23（万方平台首次上网日期，不代表论文的发表时间）