Performance Analysis and Optimization of Cyro-EM Structure Determination in RELION-2

摘要：

　　REgularised LIkelihood OptimisatioN(RELION)is one of the most popular softwares used in single particle cryo-EM structure determination.Although efforts have been made to optimize the work flow of RELION,the refinement step still remains as a bottleneck for our exploration of performance improvement.In this paper,we thoroughly analyze the cause of the performance bottleneck and propose corresponding optimization for performance speedup.The experiment results show that our approach achieves a speedup of 3.17× without degrading the resolution.

关键词： Cyro-EM Performance analysis and optimization Relion

作者: Xin You Hailong Yang Zhongzhi Luan Depei Qian

作者单位: School of Computer Science and Engineering,Beihang University,Beijing 100191,China

会议类型: 国际会议

会议名称: the 12th Conference on Advanced Computer Architecture?(ACA 2018)(2018年全国计算机体系结构学术年会)

会议地点: 辽宁营口

会议语种:英文

页码: 195-209

在线出版日期: 2018-08-10（万方平台首次上网日期，不代表论文的发表时间）