The Preparation and Long-term Storage Stability of Carbomer-loaded Resveratrol Nanoethosomes Hydrogels
This work aims to develop carbomer(934,0.25%)loaded resveratrol nanoethosomes hydrogel(Res-NH)as a novel dermal formulation.Res nanoethosomes were prepared by high pressure homogenization technique,applying 1500 bar up to 15 cycles.The long-term storage stability of Res-NH was studied after stored at room temperature for 90 days.The physicochemical characteristics of Res-NH were conducted and used to evaluate the stability.The results showed that the particle size(PS),polydispersity index(PDI)and zeta potential(ZP)were 101.9±6.7nm,0.249±0.121 and-19.91±1.39 mV,respectively.After three months of storage,the Res-NH showed no significant changes in particle size and PDI except a miner change in ZP.These results demonstrate that particle size could be a promising formulation for enhanced pharmacological activity of Res and were stable at room temperature.
nanoethosomes hydrogels resveratrol stability long-term storage
Zicong Wu Duhong Xie Wenliang Lu Zhiping Wang
School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China Health Career Academy of Changsha,Changsha 410100,China Tianjin Tasly Institute,Tianjin 300410,China
国际会议
青岛
英文
72-77
2018-11-03（万方平台首次上网日期，不代表论文的发表时间）