The Preparation and Long-term Storage Stability of Carbomer-loaded Puerarin Nanosuspension Hydrogels
This work aims to develop carbomer(934,0.25%)loaded Puerarin nanosuspension hydrogel(Pue-NH)as a novel dermal formulation.Pue nanosuspension were prepared by high pressure homogenization technique,applying 1500 bar up to 15 cycles.The long-term storage stability of Pue-NH was studied after stored at room temperature for 90 days.The physicochemical characteristics of Pue-NH were conducted and used to evaluate the stability.The results showed that the particle size,polydispersity index(PDI)and zeta potential(ZP)were 218.5 nm and-18.81 mV,respectively.After three months of storage,the Pue-NH showed no significant changes in particle size and PDI except a miner change in ZP.These results demonstrate that particle size could be a promising formulation for enhanced pharmacological activity of Pue and were stable at room temperature.
nanosuspension hydrogels puerarin stability long-term storage
Duhong Xie Wenliang Lu Zicong Wu Zhiping Wang
Health Career Academy of Changsha,Changsha 410100,China Tianjin Tasly Institute,Tianjin 300410,China School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China
国际会议
青岛
英文
78-82
2018-11-03（万方平台首次上网日期，不代表论文的发表时间）