Study of Interactions between Non-ionic Surfactants,Polyethylene Glycol,Methotrexate and Olmesartan Ester
Objective: To explore the interactions between various components of novel non-ionic surfactant vesicles,to prepare better vesicle system with higher quality and higher encapsulation efficiency,this study investigated the interactions among non-ionic Gemini surfactants,polyethylene glycol,and various drugs.Methods: Different concentrations of Gemini non-ionic surfactant solution and its mixed system with polyethylene glycol,methotrexate and olmesartan ester were prepared,and the relationship between surface tension,particle size,and potential and concentration was determined.Results: Tension measurements showed that the critical micelle concentration of Gemini surfactant was 0.5%~0.7%; 0.01%~1.0%of PEG-6000 and 0.05%~0.3%of methotrexate(mass concentration)have no effect on the surface tension of the Gemini surfactant solution.Olmesartan ester(0.01%~0.25%,mass concentration)may decrease the surface tension of the solution.Measurement results of both the particle size and the electronic potential show that there are inflection points at concentrations of 0.5%~0.7%.Conclusion: Using surface tension method and measurement of particle size and electronic potential,it can be concluded that PEG-6000 and methotrexate have no interaction with Gemini surfactants; olmesartan ester can decrease the surface tension of the solution,so better effects may be obtained if it is mixed with Gemini surfactants.
Gemini non-ionic surfactant polyethylene glycol methotrexate olmesartan ester surface tension particle size electronic potential
Shanshan Sun Huiyun Wang Lin Ding Xiangao Quan Yanzhi Li
Jining Medical University,Rizhao,Shandong,276826
国际会议
青岛
英文
254-262
2018-11-03（万方平台首次上网日期，不代表论文的发表时间）