STUDIES ON SUZUKI COUPLING REACTIONS OF LARGE STERICALLY HINDERED SUBSTRATES

摘要：

　　Suzuki coupling reaction of 2-(Trifluormethoxy)phenylboronic acid with 2-bromo-1,3-dichloro-5-nitrobenzene were successfully conducted by using Pd2(dba)3 as the catalyst and in satisfactory to good yields.The 4-(2-(diphenylphosphino)phenyl)morpholine was the best ligand in this reaction.Biaryl amides 8t which gained much attention in the pharmaceutical industry because of using as RORγt inhibitors could be synthesized using the product of Suzuki reaction 3a as the substrate after 2 steps.Higher yield of 8t could be got by using this method than the previous work.

关键词： Pd catalyst Suzuki coupling reaction hindered

作者: Jian Sun Zhaohui Jin Ning Xie Hong Wang Huajing Gao

作者单位: Institute of Petrochemical Technology,Jilin Institute of Chemical Technology,Chengde Street,Jilin,China

会议类型: 国际会议

会议名称: 2018 International Conference on New Materials and Intelligent Manufacturing (ICNMIM(2018年第一届新材料与智能制造国际会议))

会议地点: 吉林

会议语种:英文

页码: 24-26

在线出版日期: 2018-06-23（万方平台首次上网日期，不代表论文的发表时间）