Is There a Priority Shift in Mental Health Clinical Trials?
Mental health is the largest cost driver of healthcare. ClinicalTrials.gov is a web-based registry of trials conducted in human participants worldwide and serves as an important resource for both practice and research. We use the registry and dynamic topic modeling (DTM) methods to discover hidden topics and their evolution over last 17 years in trials in bipolar disorders. Our model suggests a priority shift from drugs to device and among populations studied in mental health trials. For example, transcranial magnetic stimulation for treatment resistant depression (TMS for TRD) trials have increased(x2= 52.99, p<0.001, n=187) while standardized drug safety and efficacy trials haave remained constant(x2= 0.72, p=0.39, n=101) and more trials focused on pediatric and adolescents (x2 = 2.98, p=0.08, n=133) may have been conducted since FDAAA 2007. We also derive unique data-driven insights in the discovered topic areas in this model based study.
Mood Disorders Patient Selection Natural Language Processing
Vibha Anand Soumya Ghosh Amit Anand
IBM T.J. Watson Research Center,Cambridge,MA,USA Center for Behavioral Health,Cleveland Clinic,Cleveland,OH,USA
国际会议
第十六届世界医药健康信息学大会((MEDINFO2017)、第二届世界医药健康信息学华语论坛(WCHIS 2017)、第15届全国医药信息学大会(CMIA 2017)
苏州
英文
280-284
2017-08-21（万方平台首次上网日期，不代表论文的发表时间）