Detecting Adverse Drug Event Signals from a Clinical CaseBase

摘要：

　　With the rapid development of medical information systems in Chinese hospitals over the last two decades, many of these organizations have accumulated astronomical amounts of structured and unstructured clinical data, including patient diagnostic data, treatment data, lab test data, etc. Secondary use of these data for research, such as Real World Evidence (RWE) studies, has the potential to improve medical quality and safety in daily clinical practice. In this study, we describe CaseBase, a Clinical Data Warehouse (CDW) that extracts structured clinical symptoms or findings and related temporal information from narrative clinical documents and integrates medication information from the CPOE system. An Adverse Drug Event (ADE) signals detection platform has also been developed based on CaseBase to analyze and visualize drugsymptom relations in clinical data. A prototype of this platform has been evaluated in a 2,000-bed hospital and some initial results are reported here.

关键词： Information Storage and Retrieval Drug-Related Side Effects and Adverse Reactions

作者: Weifeng Qin Xian Zeng Zheng Jia Xiang Zheng Huilong Duan Xudong Lu Haomin Li

作者单位: College of Biomedical Engineering and Instrument Science,Zhejiang University,Hangzhou,China The Childrens Hospital,Zhejiang University,Hangzhou,China;The Institute of Translational Medicine,Z

会议类型: 国际会议

会议名称: 第十六届世界医药健康信息学大会((MEDINFO2017)、第二届世界医药健康信息学华语论坛(WCHIS 2017)、第15届全国医药信息学大会(CMIA 2017)

会议地点: 苏州

会议语种:英文

页码: 549-553

在线出版日期: 2017-08-21（万方平台首次上网日期，不代表论文的发表时间）