The antibiotic resistome: gene flow in environments, animals and human beings
The antibiotic resistance is natural in bacteria and predates the human use of antibiotics.Numerous antibiotic resistance genes (ARGs) have been discovered to confer resistance to a wide range of antibiotics.The ARGs in natural environments are highly integrated and tightly regulated in specific bacterial metabolic networks.However, the antibiotic selection pressure conferred by the use of antibiotics in both human medicine and agriculture practice leads to a significant increase of antibiotic resistance and a steady accumulation of ARGs in bacteria.In this review, we summarized, with an emphasis on an ecological point of view, the important research progress regarding the collective ARGs (antibiotic resistome) in bacterial communities of natural environments,human and animals, i.e., in the one health settings.We propose that the resistance gene flow in nature is from the natural environments and to the natural environments; human and animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene circulation.
antibiotic resistance resistome microbiome gene flow
Yongfei Hu George F.Gao Baoli Zhu
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Aca CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Aca
国际会议
北京
英文
119-126
2018-03-29（万方平台首次上网日期，不代表论文的发表时间）