The Human Gut Antibiotic Resistome in the Metagenomic Era: Progress and Perspectives
(0) The human gut is populated by a vast number of bacteria, which play a critical role in human health.In recent years, attention has focused on the gut bacteria as a reservoir of antibiotic resistance genes (ARGs).Both culture-dependent and culture-independent methods have been applied to investigate numerous ARGs, collectively called the antibiotic resistome, harbored by gut bacteria.This has led to an increased understanding of the overall profile of the gut antibiotic resistome, although it remains incompletely understood.In this review, we summarize the recent research findings on the human gut antibiotic resistome, with an emphasis on progress achieved using the culture-independent metagenomic strategy.We also describe the features of different available ARG databases used for annotation in metagenomic analysis, discuss the potential problems and limitations in current research, and suggest several directions for future investigation.
Human gut microbiome Antibiotic resistance gene Antibiotic resistome Metagenomics Horizontal gene transfer
Yongfei Hu Baoli Zhu
CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101,China;Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China;Beijing Key Laboratory of Microbial Drug Resistance and Resistome,Beijing 100101, China
国际会议
北京
英文
137-143
2018-03-29（万方平台首次上网日期，不代表论文的发表时间）