Multi-Channel Dynamic Interfacial Printing: An Alternative Multi-Component Droplet Generation Technique for Lab in a Drop
Generation of uniform emulsion droplets mixed with multiple components is one of the key issues in the field of lab in a drop.Traditionally, droplet microfluidic chips are often served as the prime choice while designing and fabricating microfluidic chips always rely on skilled technician and specialized equipment,severely restricting its wide accessibility.In this work, an alternative technique, called multi-channel dynamic interracial printing (MC-DIP) was proposed for multi-component droplet generation.The MC-DIP device was designed modularly and could be setup manually without any microfabrication process, exhibiting full accessibility for freshmen after a brief training.This new technique owns advantages in the generation of droplets with predictable sizes and composites.Quantitative experiments of measuring minimum inhibitory concentration (MIC) value via mixing microbes and antibiotics into droplet were conducted to proving its application potential for lab in a drop.Further research on a clinical pathogenic strain revealed that this technique could be potentially applied in the clinical laboratory for antibiotic susceptibility testing.
Droplet generation Multi-component Liquid mixing MIC testing
Shenglong Liao Xinglei Tao Yingjiao Ju Jie Feng Wenbin Du Yapei Wang
Department of Chemistry, Renmin University of China, Beijing 100872, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences,
国际会议
北京
英文
172-198
2018-03-29（万方平台首次上网日期，不代表论文的发表时间）