ISCR2 is associated with the dissemination of multiple resistance genes among Vibrio spp.and Pseudoalteromonas spp.isolated from farmed fish

摘要：

　　58 multiresistant strains representing diverse genera were isolated from farmed fish in an aquaculture facility.Resistant rates of strains harboring ISCR2, an insertion sequence type element, were higher than those in which this element was absent.Full genome sequencing of a Vibrio isolate containing ISCR2 confirmed that it is associated with multiple resistance genes, many of which are of clinical relevance.We describe the structural variation within ISCR2, and its distribution throughout multiple diverse aquatic genera, including Vibrio, Shewenalla, Pseudoalteromonas and Psychrobacter, suggesting the potential role of ISCR2 in disseminating antibiotic resistance.We also observe, and experimentally verify, a novel macrolide resistance gene that is also associated with ISCR2.

关键词： ISCR2 Antibiotic resistance genes Vibrio Pseudoalteromonas

作者: Yixiang Xu Chao Wang Gang Zhang Jingjing Tian Ying Liu Xihui Shen Jie Feng

作者单位: State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Institute of Oceanology, Chinese Academy of Sciences,Qingdao 266071, China College of Life Sciences, Northwest A&F University,Yangling 712100, Shaanxi, China

会议类型: 国际会议

会议名称: 2018细菌耐药性威胁与应对研讨会

会议地点: 北京

会议语种:英文

页码: 213-218

在线出版日期: 2018-03-29（万方平台首次上网日期，不代表论文的发表时间）