Marine Sediment Bacteria Harbor Antibiotic Resistance Genes Highly Similar to Those Found in Human Pathogens
The ocean is a natural habitat for antibiotic-producing bacteria, and marine aquaculture introduces antibiotics into the ocean to treat infections and improve aquaculture production.Studies have shown that the ocean is an important reservoir of antibiotic resistance genes.However,there is a lack of understanding and knowledge about the clinical importance of the ocean resistome.We investigated the relationship between the ocean bacterial resistome and pathogenic resistome.We applied high-throughput sequencing and metagenomic analyses to explore the resistance genes in bacterial plasmids from marine sediments.Numerous putative resistance determinants were detected among the resistance genes in the sediment bacteria.We also found that several contigs shared high identity with transposons or plasmids from human pathogens, indicating that the sediment bacteria recently contributed or acquired resistance genes from pathogens.Marine sediment bacteria could play an important role in the global exchange of antibiotic resistance.
Jing Yang Chao Wang Chang Shu Li Liu Jianing Geng Songnian Hu Jie Feng
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics, Chinese Academy
国际会议
北京
英文
219-225
2018-03-29（万方平台首次上网日期，不代表论文的发表时间）