Measurement and correlation of the solubility of gossypol acetic acid and gossypol acetic acid of optical activity in different solvents
The equilibrium method was used to measure the solubility of gossypol acetic acid and gossypol acetic acid of optical activity in isopropyl alcohol,ethanol,acetic acid and ethyl acetate at temperature from 288.15 to 315.15.The Empirical equation and the Apelblat equation model were adopted to correlate the experimental data.For gossypol acetic acid,the root-meansquare deviations(RMSD)were observed in the range of 0.023-4.979 and 0.0112-0.614 for the Empirical equation and the Apelblat equation,respectively.For gossypol acetic acid of optical activity,the RMSD were observed in the range of 0.021-2.211 and 0.021-2.243 for the Empirical equation and the Apelblat equation,individually.And the maximum relative average deviation was 7.5%.Both equations offered an accurate mathematical expression of the experimental results.The calculated solubility showed a good relationship with the experimental solubility for most of solvents.This study provided valuable datas not only for optimizing the process of purification of gossypol acetic acid of optical activity in industry but also for further theoretical studies.
B Zhang H Tang X Y Liu X Zhai X C Yao
School of Pharmaceutical Science,Shihezi University,Shihezi 832002,China
国际会议
三亚
英文
1-8
2017-11-18（万方平台首次上网日期，不代表论文的发表时间）