Altered Persistence of Brain Activity in Schizophrenia during Working Memory Tasks
We studied the dynamic properties of the blood oxygenation level-dependent (BOLD) time series of patients diagnosed with schizophrenia both at resting state and during working memory tasks, by computing a key measure from complexity science, the Hurst exponent (H), using Adaptive Fractal Analysis (AFA).44 participants meeting the DSM-Ⅳ criteria for schizophrenia and 77 healthy controls underwent fMRI scanning at 3.0 T at resting state and during Paired associate Memory Task and Spatial Working Memory Task.Mean H for all the 116 brain regions extracted from Anatomical Automatic Labeling (AAL) template as well as the whole brain were generated and analyzed for each subject based on voxel by voxel time series.At resting state, 103 of 116 brain regions showed significantly reduced H, suggesting overwhelmingly less persistent spontaneous brain activity in patients with schizophrenia at whole brain level and region level.While performing working memory task, only prefrontal cortex (PFC), anterior cingulate cortex (ACC) presented significantly lower H.Either resting state or working memory tasks, H of healthy controls showed wide variation from region to region, while patients with schizophrenia were the opposite.The result provides evidence that brain activity of schizophrenia is associated with weaker persistence and more randomness in signal patterns compared to healthy controls at resting state;PFC and ACC are critical area for working memory;schizophrenia is characterized by limited resource allocation capability.
Schizophrenia Working memory Persistence FMRI Adaptive fractal analysis Hurst exponent
Huang ZHENG Jian-bo GAO
School of Computer, Electronics and Information, Guangxi University, China;Institute of Complexity Science and Big Data Technology, Guangxi University, China
国际会议
上海
英文
410-415
2018-04-15（万方平台首次上网日期，不代表论文的发表时间）