Biased Distribution of Amino Acid in Intrinsically Disordered Proteins and Regions
The analysis on structural characteristic of proteins is helpful to understand molecular mechanisms of disordered structure formation and principles of protein folding, and can provide a foundation for predicting model of intrinsically disordered proteins.In this thesis, the significance test of structural bias of amino acid monomer, dimer and trimer between disordered and ordered regions is carried out by using Fisher Exact Test.The purpose is to probe the difference of amino acid compositions between disordered and ordered regions and analyze the effect of interaction between amino acids on structural formation.The results show that there are significant different amino acid compositions between disordered and ordered regions and between different length disordered regions.It is also found that the effect of every kind of amino acid on structural formation is different by the analysis of amino acid dimer and trimer.Therefore, it is a good way to achieve the folding principles of proteins by analyzing amino acids coding.
proteins disorder structure amino acid
Zhengyu Ding Tian Feng Fangbo Nan Yu Wang Bo He
Harbin Engineering University 145 Nantong Street, Nangang District Harbin, Heilongjiang, China, 150001
国际会议
成都
英文
28-31
2018-03-12（万方平台首次上网日期，不代表论文的发表时间）