Recombination of CdHgTe Quantum Dot and Dextran-Magnetic Layered Double Hydroxide-Fluorouracil System for Cell Imaging
In this paper, we synthesized a CdHgTe type water-soluble quantum dots, combined in the next time with the drug delivery system dextran-magnetic layered double hydroxide-fluorouracil (DMF), built a new nanostructures platform QD@DMF for blending the fluorescent probe function of quantum dot together with the magnetic targeting curative effect of the DMF system.The Fluorescence spectrophotometer, Ultraviolet spectrophotometer, TEM and XRD were used to characterize the luminescent properties, particle morphology and phase characteristics of the QD@DMF samples.The experiments on cell imaging were carried out by laser con-focal scan microscopy technique.Results showed that the CdHgTe QDs could be successfully grafted onto the surface of the DMF system through electrostatic coupling, forming a special structure based on magnetic layered double hydroxide with a near-infrared emission wavelength in 575~780 nm.Compared with QDs, the QD@DMF composite could significantly improve the cell imaging effect,the label intensity increased with the magnetic field intensity and obeyed the linear relationship Dmean =1.760+0.013B.The fluorescent magnetic nanoparticles maintained not only the super-paramagnetic of DMF but also the photoluminescence properties of the QDs, implicating that the QD@DMF composite may be an effective multifunction tool for optical bio-imaging and magnetic targeted therapy.
Fluorescent magnetic nanoparticles Magnetic layered double hydroxide Near-infrared quantum dots Targeted delivery Cell imaging
QinYu Pei Rui Wang XueQin Jin GuoJing Gou
Department of Pharmaceutics, College of Pharmacy, Ningxia Medical University,Yinchuan, China 750004
国际会议
银川
英文
11-18
2017-08-16（万方平台首次上网日期，不代表论文的发表时间）