Characterization of Porous Hyaluronan/β-TCP Scaffolds Prepared through Heterogeneous Crosslinking
Porous Hyaluronan/β-tricalcium phosphate composite scaffolds were synthesized through lyophilizing and subsequent heterogeneous crosslinking method.The morphology of the composite scaffolds were investigated by scanning electron microscopy(SEM).The swelling behavior, mechanical property, degradation behavior and cell adhesion ability of samples were also studied.The results revealed that hyaluronan mainly contributed to the polymer matrix and water adsorption, whereas β-TCP acted as a reinforcement to strengthen the porous structure, while too much β-TCP would make the structure collapse.The pose size of obtained scaffolds ranges from 100μm to 200μm and the porosity decreased with the increase of β-TCP content.The degradation behavior and cell adhesion test indicated that increasing hyaluronan concentration can effectively improve the degradability of scaffolds and the incorporation of β-TCP improved the cell adhesion performance.Thus a simple way to prepare hyaluronan-based composite scaffolds was provided, which could be potentially used as an tissue engineering material.
Porous scaffold Hyaluronan β-TCP Composite Heterogeneous
Rui-Min Zhao Xian-Ya Xue You-Fa Wang
State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Peoples Republic of China
国际会议
银川
英文
29-36
2017-08-16（万方平台首次上网日期，不代表论文的发表时间）