Sodium Butyrate Ameliorates High-Concentrate Diet-Induced Inflammation in theRumen Epithelium of Dairy Goats
Introduction To increase the milk yield, high-concentrate diet is used in intensive farming.However, a high-concentrate diet induces the depression of the rumen pH.Studies have found that low pH can compromise the integrity and permeability of the rumen epithelium(Steele et al., 2011).Adecrease in the pH can increase the level of free lipopolysaccharide released from dead Gram-negative bacteria (Gozho et al., 2007),which will bind with TLR4, trigger the activation of NF-κB signaling pathway and initiate the inflammatory response.Studies showed that sodium butyrate (SB) can suppress the inflammatory response by reducing the activation of NF-κB (Luhrs et al., 2002) and abolish the LPS-induced cytokines expression (Segain et al., 2000).Whats more, SB promoted the growth of rumen epithelium of calves (Gorka et al.,2011) and attenuates the inflammation and mucosal lesion in experimental acute ulcerative colitis (Vieira et al., 2012).The purpose of this study was to evaluate the role of sodium butyrate plays in high-concentrate diet-induced inflammation in rumen epithelium.
Hongyu Dai Xinxin Liu Jinyu Yan Zain ul Aabdin Muhammad Shahid Bilal Xiangzhen Shen
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R.China
国际会议
The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)
北京
英文
203-206
2017-05-05（万方平台首次上网日期，不代表论文的发表时间）