Aflatoxin B1 exposure causes alterations in lipid oxidation, and carbohydrate and amino acid metabolisms in dairy goats using metabolomic analysis
Introducion Aflatoxin B1 (AFB1), one of the mycotoxins, can reduces performance, alters blood profiles, decreases immune function, and influences antioxidant status as well as liver function in animals (Bennett & Klich, 2003).AFB 1 is a biosynthetic inhibitor both in vivo and in vitro, which not only affects different metabolic pathways, such as glycogenolysis/glycolysis (Kiessling & Adam, 1986) and phospholipidation (Hsieh et al.1988), but also changes amino acid transportation (Mclean & Dutton, 1995).Metabonomics is a powerful approach to delineating the global metabolic profiling of living organisms and capturing the subtle metabolic alterations associated with physiological and pathological stimulations.The objectives of this study were using metabonomics ways to investigate the endogenous metabolic changes induced by AFB1 exposure and to further our understanding of AFB1 toxicity at the systemic level.
Jianbo Cheng Shuai Huang Caiyun Fan Nan Zheng Yangdong Zhang Shengguo Zhao Songli Li Jiaqi Wang
College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, P.R.China;Ins College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, P.R.China Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China
国际会议
The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)
北京
英文
258-260
2017-05-05（万方平台首次上网日期，不代表论文的发表时间）