Leucine regulates α-amylase and trypsin synthesis via mammalian target of rapamycin (mTOR) signaling in vitro cultivation of dairy calf pancreatic tissue
Introduction Starch is an important energy source for ruminant, its digestion in the small intestines is low to a large extent due to a shortage of synthesed α-amylase (Harmon, 1992).So an obvious strategy to improve the starch digestion in the small intestines of the dairy cow is to enhance synthesis of α-amylase.The mammalian target of rapamycin (mTOR) signaling pathway, which acts as a central regulator of protein synthesis (Kimball and Jefferson, 2002, Escobar et al., 2006), can be activated by branched-chain amino acids (BCAA),especially leucine.Our objective was to investigate the effects of leucine on the mTOR signaling pathway and to define the associations between these signaling activities and pancreatic enzymes synthesis in an in vitro model using cultured pancreatic tissue.
L.Guo C.Zheng B.L.Liu J.H.Yao
College of Animal Science and Technology, Northwest A &F University, Yangling Shaanxi, China, 712100
国际会议
The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)
北京
英文
318-322
2017-05-05（万方平台首次上网日期，不代表论文的发表时间）