The feeding of high-concentrate diet caused inflammatory responses in the liver of dairy cows
Introduction A major challenge to the current feeding systems of dairy cattle is how to support the high milk production.High concentrate diet always been used in dairy farm in recent years, however, it will cause rumen disorders and contributes to the occurrence of subacuteruminal acidosis(SARA) (Plaizier et al., 2008;Enemark., 2008;Zebeli et al.,2012).Under SARA condition, the concentration of lipopolysaccharide (LPS)increases in digestive tract and also can be translocated into blood circumstances (Plaizier et al.,2012).Then, LPS goes into the liver through portal vein.After that, LPS can be recognized by Toll-like receptor4 on liver macrophages or blood monocytes, and activate inflammatory pathways such as mitogen-activated protein kinase(MAPK) and NF-κB signaling pathways followed by the induction of pro-inflammatory cytokines.The pro-inflammatory cytokines stimulate liver to secret acute phase proteins such as Haptoglobin (Hp), LPS-binding protein (LBP) and serum amyloid A (SAA)(Broom et al., 2009;Wang et al., 2010;Tornatore et al., 2012).The objective of this study was to investigate the inflammatory responses in the liver of dairy cows caused by High-concentrate diet.
Junfei Guo Guangjun Chang Kai Zhang Tianle Xu Xiangzhen Shen
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, P.R.China
国际会议
The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)
北京
英文
326-329
2017-05-05（万方平台首次上网日期，不代表论文的发表时间）