Epigenetic mechanisms contribute to decrease SCD1 expression in the liver of dairy cows after prolonged feeding of high-concentrate diet
Introduction Adequately feeding high yielding dairy cows is a long standing problem.Feeding high concentrate diets might provide enough energy to allow for fully exploiting their genetic potential for milk synthesis, but this bears the risk in the daily practice to eliciting nutritional deficiency diseases such as Sub-acute Ruminal Acidosis (SARA)(Kleen et al., 2003).Clinically, this disease includes reduced milk synthesis and the induction of inflammatory responses(Bauman and Griinari, 2001, Zebeli and Ametaj, 2009, Colman et al.,2010, Loor et al., 2016).The enzyme Stearoyl-CoA desaturase 1 (SCD1) introduces a cis-9 bond into saturated fatty acids and plays pivotal role in regulating the formation of triglycerids and cholesterol esters influences milk composition and milk yield of the cow(Moioli et al., 2007, Maryam et al., 2016).Regarding potential mechanisms downregulating SCD1 transcription in the liver during SARA, we hypothesized that this may in part be conveyed by reducing SREBP1 binding of the SCD1 promoter, perhaps through higher compaction of its binding site.
T.Xu H.M.Seyfert X.Shen
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R.China;Leibniz Institut Leibniz Institute for Farm Animal Biology, Institute for Genome Biology, Dummerstorf, Germany College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R.China
国际会议
The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)
北京
英文
336-339
2017-05-05（万方平台首次上网日期，不代表论文的发表时间）