会议专题

The effects of Selenium to protect bovine mammary epithelial cells from oxidative damage induced by H202

Introduction The rapid development of mammary gland and a large number of the synthesis and secretion of milk in the dairy cows during periparturient and early lactation periods are main factors affecting the generation of active oxygen radicals.When these free radicals can not be cleared in time or beyond the bodys antioxidant systems ability to clear, they will accumulate in the breast tissue to destroy the cell membrane structure(Valko Met al., 2007).Selenium (Se) could enhance glutathione peroxidase1 (GPX1) and thioredoxin reductasel(TrxR1) activity and improve the antioxidant function of dairy cows, relieving the oxidative stress (J.Gong et al., 2014), but it is not clear about its mechanism.Reactive Oxygen Species (ROS) ROS is one of the major oxygen free radicals that cause oxidative stress in cells.The oxidative damage model of bovine mammary epithelial cells (BMEC) was successfully established by using H2O2 as the stress source in our previous study (L.Jin et al., 2014).In this test we use H2O2 to induce oxidative damage of BMEC, to study prevention and protection effect of Se on oxidative damage to BMEC, and provide a theoretical basis for the discussion of antioxidant mechanism of Se.

Y.G Zheng Y.M.Guo J.Gong S.M.Yan B.L.Shi X.Y.Guo

College of Animal science, Inner Mongolia Agricultural University, Zhao wu da Road 306, Saihan District,Hohhot 010018, P.R.China

国际会议

The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)

北京

英文

347-348

2017-05-05(万方平台首次上网日期,不代表论文的发表时间)