Akt1 is an essential kinase in regulating lipid biosynthesis on goat mammary epithelial cells
Introduction The protein Akt is a central mediator in PI3K/Akt signaling pathway, regulating a series of biological processes (Engelman et al., 2006, Liu et al., 2009).In lipid metabolism, activation of Akt1 regulates lipogenic genes, including FASN, SCD and SREBP1, promotes processing of SREBP1 protein, and increases the concentration of cellular fatty acids and phosphoglycerides (Porstmann et al., 2005, Yecies et al., 2011).Akt-dependent activation of lipogenesis requires activation of mTOR, the downstream atypical serine/threonine protein kinase that belongs to PI3K-related kinase family (Hassan et al., 2013).In lactating mice mammary, Akt1 is supposed to maintain the function of lactation and synthesize sufficient milk to support their offspring, and loss of Akt1 results in a failure in regulating cellular metabolism including lipid synthesis.In the present work, goat Akt1 gene was cloned and in vitro studies on goat mammary epithelial cells (GMECs) were developed, aiming at investigating the roles of Akt1 on goat mammary fatty acid metabolism.
T.Y.Zhang Y.Q.Yi X.Y.Zhang Y.Ma H.P.Shi
Shanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology,Northwest A&F University, Yangling, 712100, PR China
国际会议
The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)
北京
英文
376-378
2017-05-05（万方平台首次上网日期，不代表论文的发表时间）