Metabolomics reveals alterations in bovine mammary epithelial cells metabolism relate to the signaling pathway of protein synthesis with different essential amino acid ratios
Introduction Low efficiency of milk protein synthesis is the serious problem to dairy industry, only up to 38％ of the total amino acid (AA) flux is used for milk protein synthesis, which resultseconomic costs and dietary nitrogen (N) emission(Toerien et al., 2010).Therefore, it is emergent to improve milk protein synthesis and AA utilization efficiencyBalancing essential amino acid (EAA) profile can improve milk protein synthesis (Haque et al., 2015).It has been demonstrated that the most limiting EAA, Lys and Met, which with the ideal ratio of Lys to Met (～3∶1) could promote milk protein synthesis(Nan et al., 2014).But very few experiments were performed to study the effect of potential limiting amino acid (Ile, Leu Val and Thr) on milk protein synthesis regulation.Therefore, the objective of this research is to study the mechanism of milk protein synthesis in response to different EAA ratios in MAC-T cells.
X.W.Dong Z.Zhou L.Wang B.Saremi Z.S.Wang J.J.Loor
Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrit Department of Animal Sciences, University of Illinois, Urbana 61801 Southwest University, Rongchang,Chongqing, P.R.China Evonik Nutrition & Care GmbH, 63457 Hanau-Wolfgang, Germany Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrit
国际会议
The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)
北京
英文
385-388
2017-05-05（万方平台首次上网日期，不代表论文的发表时间）