Metabolomics reveals alterations in MAC-T cells metabolism relate to the signaling pathway of protein synthesis with different ratios of Lys to Met
Introduction Amino acid (AA) is not only the precursor of protein but also the signaling molecule to regulate protein synthesis(Appuhamy et al., 2012).It has been confirmed that Met and Lys are the most limiting AA,which could promotes milk protein synthesis through the regulation of mTOR phosphorylation with thetheoretical ratio of Lys to Met (3∶1) in bovine mammary epithelial cells(Nan et al., 2014).However, there were very few studies pay attentions on the whole mTOR pathway in response to the variation of intracellular metabolism induced by different ratios of Lys to Met.Therefore, the objective of this research is to study the mechanism of milk protein synthesis by metabolomics technology in MAC-T cells.
X.W.Dong Z.Zhou L.Wang B.Saremi Z.S.Wang J.J.Loor
Department of Animal Sciences, University of Illinois, Urbana 61801;Key Laboratory for Animal Diseas Department of Animal Sciences, University of Illinois, Urbana 61801 Southwest University, Rongchang,Chongqing, P.R.China Evonik Nutrition & Care GmbH, 63457 Hanau-Wolfgang, Germany Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education, Animal Nutrit
国际会议
The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)
北京
英文
389-392
2017-05-05（万方平台首次上网日期，不代表论文的发表时间）