Annexin A2 promotes milk synthesis in bovine mammary epithelial cells through mTOR signaling pathway
Introduction Annexin A2 (AnxA2), a member of the Annexin family of Ca2+ dependent phospholipid binding protein (Gerke et al., 2002).Annexins contain a variable N-terminal region (head domain) leading to the diversity of functions and biological activities, and a conserved C-terminal core (conserved domain)composed of four or eight homologous repeats of about 70 amino acids, each of which contains the annexins motif for calcium binding (Gerke et al., 2002).Annexins are classified into A to E family, and higher animal express 12 groups (AnxA1-All and AnxA13), AnxAs are widely distributed among eukaryotes but largely absent in prokaryotes and yeasts, which are localized in cytoplasmic, nuclear and the attached, loosely or closely, to the plasma membrane (Boudhraa et al., 2016).Annexins mainly participate in cell proliferation, growth, movement, metabolism, apoptosis they also play important roles in cytoskeletal organization, exocytosis, endocytosis, invasion, metastasis (Peng et al., 2014;Mirsaeidi et al.,2016).Our research group previously found that AnxA2 could mediate the signal of amino acids and affect milk synthesis of bovine mammary epithelial cells (BMEC).The objectives of the present study were to determine whether AnxA2 could play regulation functions related to milk synthesis in BMEC.
M.H.Zhang Y.Liu B.Qu X.H.Yuan J.X.Ao X.J.Gao
The Key Laboratory of Dairy Science of Education Ministry, Northeast Agricultural University, Harbin 150030, P.R.China
国际会议
The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)
北京
英文
393-394
2017-05-05（万方平台首次上网日期，不代表论文的发表时间）