Modulation of intestinal epithelial permeability in differentiated Caco-2 cells exposed to aflatoxin M1 and ochratoxin A individually or collectively
Introduction It is undoubted that indirectly intake of foods of animal origin such as milk and eggs, which obtained from animals that were fed with mycotoxins contaminated material, could lead to human exposure to mycotoxins (Capriotti et al., 2012).Thus, it would be possible to produce a detrimental effect on individuals health, if milk is contaminated by mycotoxins (Flores-flores, 2015).The gastrointestinal tract (GIT) is the first tissue barrier to come into contact with food contaminants, such as mycotoxins(Galarza-Seeber et al., 2016;Gambacorta et al., 2016).The GIT barrier is constituted by intercellular tight junction (TJ) proteins that localize to the apical domain of epithelial cells(Qasim et al.,2014;Suzuki, 2013).Therefore, there is likely that the defects in intestinal epithelial barrier functioncaused by mycotoxins frequently areassociated with the disruption of TJ-integrity.Hence,it is crucial to further understand the individual and combined effectof the AFM 1 and OTA, which are common co-occurrence in milk, on the structure and function ofthe gut.The purpose of this study was to investigate the individual and combined effects of AFM1 and OTA on intestinal permeability and define the underlying mechanism(s).
Y.N.Gao J.Q.Wang C.C.Luo N.Zheng
Ministry of Agriculture-Key Laboratory of Quality & Safety Control for Milk and Dairy Products, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China
国际会议
The 5h International Symposium on Dairy Cow Nutrition and Milk Quality(第五届“奶牛营养与牛奶质量国际研讨会)
北京
英文
401-404
2017-05-05（万方平台首次上网日期，不代表论文的发表时间）