Effects of dietary supplementation of a purified nucleotide mixture on immune function and disease and stress resistance in channel catfish,Ictalurus punctatus
Juvenile channel catfish (14.4g average initial weight) were fed diets supplemented with a purified nucleotide mixture for 8 weeks.The mixture consisted of five nucleotides supplied on an equal basis as disodium salts at combined concentrations of 0 (control), 0.1%, 0.3%, 0.9% or 2.7% of diet.Addition of nucleotides to diet produced a dose-dependent reduction in survival of channel catfish to Edwardsiella ictaluri.Although the reasons are unclear, the high levels of nucleotides supplemented in this study may have contributed to the decrease in disease resistance, and this decrease appeared to be unrelated to the innate immune (unaffected) and specific antibody (enhanced) responses.Stress resistance increased with a corresponding amelioration of the immunosuppressive effects of the stress response on non-specific immunity (lysozyme and bactericidal activity) as nucleotides increased in diet.Use of exogenous nucleotides as a prophylactic treatment before culture-related stress exposure may prove beneficial by decreasing the immunosuppressive effects of stress but not in prevention of ESC.
cortisol Edwardsiella ictaluri enteric septicaemia immunity
Thomas L Welker Chhorn Lim Mediha Yildirim-Aksoy Phillip H Klesius
Aquatic Animal Health Research Laboratory, United States Department of Agriculture, Agricultural Research Service,Auburn, AL, USA
国际会议
广州
英文
110-121
2017-03-01（万方平台首次上网日期，不代表论文的发表时间）