Controlling Cellular Uptake of Nanoparticles with pH-Sensitive Polymers
Uderstanding the interactions between pH-responsive nanoparticles and cell membranes, for example, how to efficiently transport functional nanoparticles into cancer tumors without doingany damage to healthy tissuesis of great importance in biomedicine.In this work,the designed guidelines for nanoparticle in drug/gene delivery will be systematically discussed.In part one, by using dissipative particle dynamics, one new type of triply pH-responsive drug delivery system with the addition of pH-sensitive polymers for controlling the cellular uptake of nanoparticles under different pH environments will be reported.We find that the uptake behaviors of designed nanomaterials can show triple-pH-responsive, which may have some advantages over previous experimental pH-responsive materials in multi-pH systems.And in part two, with the help of computer simulation, we will clarify the role of DNA in the cellular uptake of gene nanovectors, which is usually overlooked in previous experimental studies.Besides, we will also compare the uptake behaviors between normal and cancer cells.
Nanoparticle Cell Membrane pH-Sensitive Polymer Computer Simulation
Hong-ming Ding Yu-qiang Ma
Soft Condensed Matter Physics Lab, National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093, China
国际会议
昆明
英文
58-60
2014-05-01（万方平台首次上网日期，不代表论文的发表时间）