High Strength Injectable Supramolecular Polymer Hydrogels
Hydrogels consisting of water swollen chemically or physically crosslinked polymer networks are being exploited as a wide range of biomedical applications such as cell scaffolds, soft tissue substitutes and bioactuators.However, their load-bearing applications are often limited by the poor mechanical performances.Chemical crosslinkers are generally essential for the construction of high-strength hydrogels;however, the resultant gels tend not to be injectable or reprocessable.Herein, we reported high strength injectable supramolecular polymer (SP) hydrogels synthesized from amino acid derivative-based monomer containing multiple hydrogen bonding interactions on side chains.The SP hydrogels demonstrated thermoplastic processability, injectability and self-healability.Also an autolytic thermoresponsive high strength hydrogel capable of responding to calcium ions and pH can be readily fabricated by tuning the end-groups on side chains.The SPs were implanted into the articular cartilage defects of rabbits.Initial in vivo results suggest that the SPs hydrogels are promising to be novel biomedical scaffolds for potential biomedical applications.
Xiyang Dai Fei Gao Yinyu Zhang Wenguang Liu
School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China
国际会议
9th International Symposium on High-Tech Polymer Materials(第9届国际高技术高分子材料学术会议)(HTPM-9)
郑州
英文
35-35
2016-07-11（万方平台首次上网日期，不代表论文的发表时间）