Hollow Hydroxyapatite/Polyelectrolyte Hybrid Microparticles with Controllable Size, Wall Thickness and Drug Delivery Properties
Hollow hydroxyapatite/chitosan/hyaluronic acid (H-HAP/CHI/HA) hybrid microspheres with controllable size, wall thickness and drug delivery properties were prepared by controlling the hydrothermal conversion time.The prepared H-HAP/CHI/HA hybrid microparticles were characterized by TEM, SEM and FT-IR spectrometer.With the extension of hydrothermal conversion time, the thickness of the HAP shell could become thicker, and the size of the hybrid hollow microparticles changed from 2 m to 850nm (Fig.1).The DOX loading and release results demonstrated that the HAP/CHI/HA hybrid microspheres had a relatively high drug loading efficiency.The drug release rate of hybrid microsphere increased with the hydrothermal conversion time increasing.At the same time,the introduction of CHI/HA polymer film could potentially assuage the initial burst release of drug from the porous HAP.1 In addition, the drug release of hollow hybrid HAP microparticles was pH-dependent because of the different electrostatic interaction in the CHI/HA multilayers at different pH values and the dissolution of the HAP hollow core under acidic conditions (Fig.2).
Jing Wei Jun Shi ShaoKui Cao
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
国际会议
9th International Symposium on High-Tech Polymer Materials(第9届国际高技术高分子材料学术会议)(HTPM-9)
郑州
英文
149-149
2016-07-11（万方平台首次上网日期，不代表论文的发表时间）