In Situ Functionalization of Hollow Mesoporous Hydroxyapatite with Thermal-Responsive Gates in Supercritical CO2
During the past decade, mesoporous microparticles have attracted increasing attention because of their unique characteristics such as extraordinarily high specific surface area, large pore volume, tunable pore size and well-defined ordered mesostructure, which are crucial for developing new types of drug delivery carriers.1 As a major inorganic constituent of teeth and bones, hydroxyapatite (Ca10(PO4)6(OH)2,HAP) has been an excellent candidate for biomedical application because of their outstanding biological activity, biocompatibility and biodegradability.Herein, we describe a novel method based on in situ functionalization of hollow mesoporous HAP (H-HAP) with thermal-responsive aliphatic poly(urethane-amine) (PUA) for smart drug delivery, which shows promising potential as smart drug carrier (Fig.1).Thermal-responsive PUA acted as the on-off gates inside the mesoporous H-HAP due to the stretch and shrinkage of the PUA polymer chains at different temperatures.Firstly, H-HAP microparticles and 2-methylaziridine were introduced into the autoclave filled with N2.The reactor was pressurized succeedingly with compressed CO2 to 10 MPa.After stirring at 100 ℃ for 24 h, the reaction was stopped by cooling the autoclave in an ice bath.The product (PUA-g-H-HAP) was washed by methanol for three times and collected by centrifugation.The drug release results showed that the PUA-g-H-HAP microparticles exhibited sustained and pH/thermal-responsive drug release property (Fig.2), and PUA on-off gates enabled the DOX release in a reversible way by simply adjusting the environmental temperature.
Qiong Wu Jun Shi Shaokui Cao
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450052, China
国际会议
9th International Symposium on High-Tech Polymer Materials(第9届国际高技术高分子材料学术会议)(HTPM-9)
郑州
英文
150-150
2016-07-11（万方平台首次上网日期，不代表论文的发表时间）