High Mechanical Strength Microfibrillated Cellulose (MFC)/Genipin-Gelatin Composite Hydrogel
Once damaged, articular cartilage has very little capacity for spontaneous healing, due to the avascular nature of the tissue1.Tissue engineering approaches have been demonstrated tremendous clinical potential for regeneration of hyaline-like cartilage tissue and treatment of chondral lesions.Scaffolds represent one of the key components for tissue engineering approach2.Hydrogels are highly absorbent natural or synthetic polymeric networks.Hydrogels also possess a degree of flexibility very similar to natural tissue, due to their significant water content.Hydrogels are promising scaffold for tissue engineering3.However, most hydrogels have low mechanical strength, which limits their application as a scaffold4.The matrix of articular cartilage is specialized connective tissue which consists mainly of a hydrated proteoglycan gel reinforced by a three-dimensional network of collagen fibrils.This combination of fiber and hydrated gel is unique adapted to the dual functions of low friction articulation at the joint surface, and load transmission across the joint to the underlying bone.
Qiannan Zhang Wenjing Jin Liwei Wang Tingting Yan Xiaoxiao Li Xuejing Zheng Keyong Tang
School of Material Science and Engineering, Zhengzhou University, 45001, Zhengzhou
国际会议
9th International Symposium on High-Tech Polymer Materials(第9届国际高技术高分子材料学术会议)(HTPM-9)
郑州
英文
153-154
2016-07-11（万方平台首次上网日期，不代表论文的发表时间）