High Mechanical Strength Dialdehyde Microfibrillated Cellulose/Gelatin Composite Hydrogel
Tissue engineering is an effective way for the regeneration of cartilage.Scaffolds represent one of the key components for tissue engineering approach.1 Natural and synthetic materials have been investigated as scaffolds for cartilage repair.Collagen and gelatin are widely used natural materials due to their chemical and structural similarity to cartilage.2,3 However, as most natural polymeric materials,gelatin scaffold lacks mechanical properties and shows rapid degradation in vivo.Extensive research has focused on mixtures of gelatin with other biological materials for a composite with improved mechanical properties and stability.Cellulose is a large, linear-chain polymer with an abundance of hydroxyl groups,good biocompatibility, and unique physicochemical properties.Cellulose-based scaffold is also attractive for cartilage tissue engineering.4 By combining cellulose and gelatin, hydrogen bonds will form and being the major conjugate force between them, cellulose will act as a scaffold, and gelatin will be filled in its network.This composite can be reinforced by crosslinking the two components, various crosslinking agents including caibodiimide, genipin, glutaralde, and chondrointin sulfate have been used to chemically crosslink gelatin chains.However, crosslinking agents always cause toxicity preventing cells multiply.
Qiannan Zhang Wenjing Jin Liwei Wang Tingting Yan Xuejing Zheng Keyong Tang
College of Materials Science and Engineering, Zhengzhou University, Henan Zhengzhou, 450001
国际会议
9th International Symposium on High-Tech Polymer Materials(第9届国际高技术高分子材料学术会议)(HTPM-9)
郑州
英文
159-160
2016-07-11（万方平台首次上网日期，不代表论文的发表时间）