A novel N-doped carbon nanotube fiber for selective and reliable electrochemical determination of ascorbic acid in rat brain microdialysates
Selective and reliable method is of great importance for in vivo analysis in the complicated brain.In thiswork,we developed a new approach for detection of ascorbic acid (AA) based on a new nitrogen-doped nanotube fiber (NCNF) microelectrode.After electrochemical pre-treatment,the NCNF microelectrode (e-NCNF) demonstrated high electrocatalytic capability for AA oxidation with a low working potential,0 V,resulting in high selectivity for detection of AA level against other biological species in brain,as well as producing high sensitivity.Moreover,the e-NCNF was directly assembled by carbon nanotube bundles,free from the post-modification,thus showing high reproducibility,in which the deviation of anodic current intensity of six electrodes prepared with same method did not exceed 4% (RSD,n=6).Based on the remarkable analytical performance,the e-NCNF with good biocompatibility was successfully applied to determine the AA level as 134 ± 7 mM,in rat brain microdialysates.
Carbon nanotube fiber Ascorbic acid Rat brain Electrochemical determination Reliable
Feifei Cao Limin Zhang Yang Tian
Shanghai Key Laboratory of Green Chemistry and Chemical Processes,Department of Chemistry,School of Chemistry and Molecular Engineering,East China Normal University,Dongchuan Road 500,Shanghai 200243,China
国际会议
南京
英文
278-283
2016-12-23（万方平台首次上网日期，不代表论文的发表时间）