A novel ultrasensitive competition strategy for electrochemical and colorimetric cytosensing of acute leukemia cells
Selective and reliable method is of vital importance for acute leukemia detection.In this work,a robust competitive electrochemical and colorimetric cytosensing platform for detection of acute leukemia cells was developed with high sensitivity,selectivity,acceptable rapidity and excellent extensibility.The joint effects of the high catalytic activity of horseradish peroxidase (HRP)-mimiking DNAzyme toward H2O2 reduction and the excellent competing reaction contributed to the greatly enhanced sensitivity.Such a dual mode sensing strategy allows for ultrasensitive acute leukemia cytosensing with a detection limit as low as ~4 cells and a wide linear response range from 102 to 107 cells per mL.This electrochemical and colorimetric cytosensing approach holds great promise as a new point-of-care diagnostic tool for early detection of human acute leukemia and may be readily expanded to multiplex cytosensing of other cancer cells.
Electrochemical Colorimetric Acute leukemia Cytosensing Competition strategy
Tingting Zheng Jiaju Fu Liping Jiang Jun-Jie Zhu
Department of Chemistry,School of Chemistry and Molecular Engineering,East China Normal University,S State Key Laboratory of Analytical Chemistry for Life Science,School of Chemistry and Chemical Engin
国际会议
南京
英文
418-422
2016-12-23（万方平台首次上网日期，不代表论文的发表时间）